Assay Detail
Binding
CHEMBL5126697
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Inhibition of human cathepsin B
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Peptidomimetic nitrile warheads as SARS-CoV-2 3CL protease inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.07 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3427166 | — | — | 1 | 5.85 |
| CHEMBL4851462 | — | — | 1 | 5.70 |
| CHEMBL5170425 | — | — | 1 | 4.75 |
| CHEMBL5180730 | — | — | 1 | 4.55 |
| CHEMBL5185160 | — | — | 1 | 4.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3427166 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4851462 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5170425 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL5180730 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL5185160 | — | IC50 | = | 32000.0 | nM | 4.50 |