Assay Detail
Binding
CHEMBL5126733
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HDAC8 in human HeLa nuclear extract using Boc-Lys(Ac)-AMC as substrate
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Small-molecule inhibitors of breast cancer-related targets: Potential therapeutic agents for breast cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.46 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4786350 | — | — | 1 | 8.48 |
| CHEMBL4788954 | — | — | 1 | 8.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4786350 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL4788954 | — | IC50 | = | 3.6 | nM | 8.44 |