Assay Detail

CHEMBL5126809

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Functional

Antiproliferative activity against human KB cells assessed as cell growth inhibition

ChEMBL ↗

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Target

KB (CHEMBL398) ↗

Open DB target context

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Primary target KB

CHEMBL398

Anchored from Assay target.

Protein identity KB

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	KB
Confidence	1 — Organism
Curated By	Autocuration

Target

KB (CHEMBL398) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Renieramycin-type alkaloids from marine-derived organisms: Synthetic chemistry, biological activity and structural modification.

Fang Y, Li H, Ji B, Cheng K, Wu B, Li Z, Zheng C, Hua H, Li D.
Eur J Med Chem (2021) 210 : 113092 -113092
PubMed 33333398 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.67	8.67

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL5196001	—	—	1	8.67

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL5196001	—	IC50	=	2.12	nM	8.67