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Assay Detail

CHEMBL5126846

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Binding
Binding affinity to human adenosine A3A receptor
13
Total Activities
13
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Adenosine receptor A3 (CHEMBL256)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Adenosine receptor antagonists: Recent advances and therapeutic perspective.
Saini A, Patel R, Gaba S, Singh G, Gupta GD, Monga V.
Eur J Med Chem (2022) 227 : 113907 -113907
PubMed 34695776 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 9 7.00 8.92
IC50 4 6.73 6.79

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4294479 1 8.92
CHEMBL2311746 1 8.15
CHEMBL2312110 1 8.15
CHEMBL4292012 1 7.82
CHEMBL5192200 1 6.91
CHEMBL4092103 1 6.79
CHEMBL4069012 1 6.76
CHEMBL4070079 1 6.73
CHEMBL3087710 1 6.71
CHEMBL4075640 1 6.63
CHEMBL3087712 1 6.04
CHEMBL445184 1 5.62
CHEMBL4081648 1 4.66

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4294479 Ki = 1.21 nM 8.92
CHEMBL2311746 Ki = 7.0 nM 8.15
CHEMBL2312110 Ki = 7.0 nM 8.15
CHEMBL4292012 Ki = 15.3 nM 7.82
CHEMBL5192200 Ki = 124.0 nM 6.91
CHEMBL4092103 IC50 = 163.0 nM 6.79
CHEMBL4069012 IC50 = 172.0 nM 6.76
CHEMBL4070079 IC50 = 187.0 nM 6.73
CHEMBL3087710 Ki = 193.0 nM 6.71
CHEMBL4075640 IC50 = 235.0 nM 6.63
CHEMBL3087712 Ki = 906.0 nM 6.04
CHEMBL445184 Ki = 2400.0 nM 5.62
CHEMBL4081648 Ki = 22000.0 nM 4.66