Assay Detail
Functional
CHEMBL5126987
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 2-MeS-ADP induced P2Y12 (unknown origin) signalling expressed in CHO cells membrane incubated for 45 mins by 35S-GTPgammaS assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
P2Y<sub>12</sub> antagonists: Approved drugs, potential naturally isolated and synthesised compounds, and related in-silico studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.69 | 9.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5176593 | — | — | 1 | 9.48 |
| CHEMBL5187308 | — | — | 1 | 7.00 |
| CHEMBL5190691 | — | — | 1 | 6.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5176593 | — | IC50 | = | 0.33 | nM | 9.48 |
| CHEMBL5187308 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5190691 | — | IC50 | = | 260.0 | nM | 6.58 |