Assay Detail
Binding
CHEMBL5127020
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of DYRK1A (unknown origin)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (CHEMBL2292) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Therapeutic potential of quinazoline derivatives for Alzheimer's disease: A comprehensive review.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.96 | 9.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2386747 | — | — | 1 | 9.66 |
| CHEMBL3894571 | — | — | 1 | 9.44 |
| CHEMBL2386748 | — | — | 1 | 9.03 |
| CHEMBL2386764 | — | — | 1 | 9.01 |
| CHEMBL3971170 | — | — | 1 | 9.00 |
| CHEMBL2386761 | — | — | 1 | 7.40 |
| CHEMBL2386753 | — | — | 1 | 7.33 |
| CHEMBL3823505 | — | — | 1 | 6.75 |
| CHEMBL2386744 | — | — | 1 | 6.30 |
| CHEMBL4465324 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2386747 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL3894571 | — | IC50 | = | 0.36 | nM | 9.44 |
| CHEMBL2386748 | — | IC50 | = | 0.94 | nM | 9.03 |
| CHEMBL2386764 | — | IC50 | = | 0.98 | nM | 9.01 |
| CHEMBL3971170 | — | IC50 | = | 0.99 | nM | 9.00 |
| CHEMBL2386761 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2386753 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL3823505 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL2386744 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4465324 | — | IC50 | = | 2180.0 | nM | 5.66 |