Assay Detail
Binding
CHEMBL5127257
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TXK (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Review of the development of BTK inhibitors in overcoming the clinical limitations of ibrutinib.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.68 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1873475 | IBRUTINIB | 4.0 | 1 | 8.70 |
| CHEMBL5193128 | — | — | 1 | 8.66 |
| CHEMBL4071161 | TIRABRUTINIB | 4.0 | 1 | 6.94 |
| CHEMBL5187554 | — | — | 1 | 6.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1873475 | IBRUTINIB | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5193128 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL4071161 | TIRABRUTINIB | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL5187554 | — | IC50 | = | 368.0 | nM | 6.43 |