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Assay Detail

CHEMBL5127323

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antagonist activity at P2Y1 receptor (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

P2Y purinoceptor 1 (CHEMBL4315)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Progress of thrombus formation and research on the structure-activity relationship for antithrombotic drugs.
Li X, Guo T, Feng Q, Bai T, Wu L, Liu Y, Zheng X, Jia J, Pei J, Wu S, Song Y, Zhang Y.
Eur J Med Chem (2022) 228 : 114035 -114035
PubMed 34902735 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 4 6.04 6.32

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL432028 1 6.32
CHEMBL104784 1 6.08
CHEMBL320924 1 5.96
CHEMBL108166 1 5.80

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL432028 IC50 = 480.0 nM 6.32
CHEMBL104784 IC50 = 840.0 nM 6.08
CHEMBL320924 IC50 = 1090.0 nM 5.96
CHEMBL108166 IC50 = 1600.0 nM 5.80