Assay Detail
Binding
CHEMBL5127367
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Inhibition of porcine brain GSK-3alpha/beta using YRRAAVPPSPSLSRHSSPHQpSEDEEE as substrate incubated for 30 mins in presence of ATP by scintillation counting method
49
Total Activities
49
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Tissue | Brain |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Structure-Activity Relationship in the Leucettine Family of Kinase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 49 | 5.74 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5179655 | — | — | 1 | 6.92 |
| CHEMBL5195216 | — | — | 1 | 6.92 |
| CHEMBL5200518 | — | — | 1 | 6.70 |
| CHEMBL1803085 | — | — | 1 | 6.28 |
| CHEMBL5181008 | — | — | 1 | 6.26 |
| CHEMBL5196066 | — | — | 1 | 6.25 |
| CHEMBL1802358 | — | — | 1 | 6.22 |
| CHEMBL5199422 | — | — | 1 | 6.12 |
| CHEMBL1803069 | — | — | 1 | 6.12 |
| CHEMBL5181355 | — | — | 1 | 6.05 |
| CHEMBL5195122 | — | — | 1 | 5.96 |
| CHEMBL5187895 | — | — | 1 | 5.96 |
| CHEMBL5191942 | — | — | 1 | 5.92 |
| CHEMBL5193677 | — | — | 1 | 5.89 |
| CHEMBL5206143 | — | — | 1 | 5.85 |
| CHEMBL5170033 | — | — | 1 | 5.85 |
| CHEMBL1802843 | — | — | 1 | 5.85 |
| CHEMBL5206744 | — | — | 1 | 5.77 |
| CHEMBL5187753 | — | — | 1 | 5.75 |
| CHEMBL5194491 | — | — | 1 | 5.70 |
| CHEMBL5194689 | — | — | 1 | 5.70 |
| CHEMBL5203292 | — | — | 1 | 5.68 |
| CHEMBL1803082 | — | — | 1 | 5.62 |
| CHEMBL5202202 | — | — | 1 | 5.62 |
| CHEMBL5201763 | — | — | 1 | 5.58 |
| CHEMBL1803079 | — | — | 1 | 5.39 |
| CHEMBL5173265 | — | — | 1 | 5.34 |
| CHEMBL485053 | LEUCETTAMINE B | — | 1 | 5.30 |
| CHEMBL5175458 | — | — | 1 | 5.21 |
| CHEMBL5200677 | — | — | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5179655 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL5195216 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL5200518 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1803085 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL5181008 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5196066 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL1802358 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL5199422 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL1803069 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL5181355 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL5195122 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL5187895 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL5191942 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL5193677 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1802843 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL5206143 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL5170033 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL5206744 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL5187753 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL5194491 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5194689 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5203292 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL1803082 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL5202202 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL5201763 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL1803079 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL5173265 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL485053 | LEUCETTAMINE B | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL5175458 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL5200677 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL5182235 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL5172199 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL5205905 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL5207630 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL1803084 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL5187202 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL5180765 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL5179457 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL5208980 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5207974 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5209464 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5184273 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5169649 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5181028 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5193292 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5172170 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1803080 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1802355 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1803081 | — | IC50 | > | 10000.0 | nM | - |