Assay Detail
Binding
CHEMBL5127372
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GST-fused mouse recombinant CLK3 expressed in Escherichia coli using GRSRSRSRSRSR peptide as substrate incubated for 30 mins in presence of ATP by scintillation counting method
50
Total Activities
50
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dual specificity protein kinase CLK3 (CHEMBL1075282) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Structure-Activity Relationship in the Leucettine Family of Kinase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 50 | 5.78 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1803085 | — | — | 1 | 6.55 |
| CHEMBL5181008 | — | — | 1 | 6.40 |
| CHEMBL5169780 | — | — | 1 | 6.37 |
| CHEMBL5199422 | — | — | 1 | 6.30 |
| CHEMBL5206744 | — | — | 1 | 6.29 |
| CHEMBL5196066 | — | — | 1 | 6.25 |
| CHEMBL5195122 | — | — | 1 | 6.21 |
| CHEMBL5200518 | — | — | 1 | 6.16 |
| CHEMBL5179655 | — | — | 1 | 6.10 |
| CHEMBL5203292 | — | — | 1 | 6.02 |
| CHEMBL5195216 | — | — | 1 | 5.96 |
| CHEMBL1802358 | — | — | 1 | 5.92 |
| CHEMBL5200677 | — | — | 1 | 5.92 |
| CHEMBL5208980 | — | — | 1 | 5.92 |
| CHEMBL1803069 | — | — | 1 | 5.85 |
| CHEMBL5181355 | — | — | 1 | 5.85 |
| CHEMBL5187895 | — | — | 1 | 5.68 |
| CHEMBL5191942 | — | — | 1 | 5.64 |
| CHEMBL1803082 | — | — | 1 | 5.64 |
| CHEMBL5187753 | — | — | 1 | 5.62 |
| CHEMBL5194689 | — | — | 1 | 5.62 |
| CHEMBL1802843 | — | — | 1 | 5.60 |
| CHEMBL5182235 | — | — | 1 | 5.58 |
| CHEMBL1803079 | — | — | 1 | 5.52 |
| CHEMBL5206143 | — | — | 1 | 5.51 |
| CHEMBL5175458 | — | — | 1 | 5.50 |
| CHEMBL5179457 | — | — | 1 | 5.46 |
| CHEMBL5201763 | — | — | 1 | 5.35 |
| CHEMBL5193677 | — | — | 1 | 5.28 |
| CHEMBL5207630 | — | — | 1 | 5.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1803085 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL5181008 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL5169780 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL5199422 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL5206744 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL5196066 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL5195122 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL5200518 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL5179655 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL5203292 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL5195216 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1802358 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL5200677 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL5208980 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL5181355 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1803069 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL5187895 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL5191942 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL1803082 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL5187753 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL5194689 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL1802843 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL5182235 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL1803079 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL5206143 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL5175458 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL5179457 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL5201763 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL5193677 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL5207630 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL485053 | LEUCETTAMINE B | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL5202202 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL1803081 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL5194491 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5180765 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1803080 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4063256 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1802355 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1803084 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5170033 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5172170 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5184273 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5172199 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5173265 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5205905 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5188100 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5176573 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5187202 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5207974 | — | IC50 | >= | 10000.0 | nM | - |
| CHEMBL5209464 | — | IC50 | > | 10000.0 | nM | - |