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Assay Detail

CHEMBL5127629

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Agonist activity at human KOP stably expressed in CHO cells
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Kappa-type opioid receptor (CHEMBL237)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Analgesic Opioid Ligand Discovery Based on Nonmorphinan Scaffolds Derived from Natural Sources.
Smith MT, Kong D, Kuo A, Imam MZ, Williams CM.
J Med Chem (2022) 65 : 1612 -1661
PubMed 34995453 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 1 10.11 10.11

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2381583 22-THIOCYANATOSALVINORIN A 1 10.11

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2381583 22-THIOCYANATOSALVINORIN A EC50 = 0.077 nM 10.11