Assay Detail
Binding
CHEMBL5127750
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Inhibition of PARP1 (unknown origin) incubated for 1 hr by chemiluminescence assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Recent advances in DDR (DNA damage response) inhibitors for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.63 | 9.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5176874 | — | — | 1 | 9.60 |
| CHEMBL5188771 | — | — | 1 | 9.23 |
| CHEMBL4461382 | — | — | 1 | 9.11 |
| CHEMBL4438741 | — | — | 1 | 8.43 |
| CHEMBL4470724 | — | — | 1 | 8.31 |
| CHEMBL4744783 | — | — | 1 | 8.20 |
| CHEMBL4758337 | — | — | 1 | 8.14 |
| CHEMBL4541731 | — | — | 1 | 8.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5176874 | — | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL5188771 | — | IC50 | = | 0.59 | nM | 9.23 |
| CHEMBL4461382 | — | IC50 | = | 0.78 | nM | 9.11 |
| CHEMBL4438741 | — | IC50 | = | 3.75 | nM | 8.43 |
| CHEMBL4470724 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL4744783 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL4758337 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL4541731 | — | IC50 | = | 9.6 | nM | 8.02 |