Assay Detail
Functional
CHEMBL5127784
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Inhibition of cell proliferation in human NCI-H1299 cells incubated for 3 days by MTT assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1299 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Recent advances in DDR (DNA damage response) inhibitors for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 9.78 | 9.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5204322 | — | — | 1 | 9.98 |
| CHEMBL5176563 | — | — | 1 | 9.81 |
| CHEMBL1976040 | ADAVOSERTIB | 2.0 | 1 | 9.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5204322 | — | IC50 | = | 0.1054 | nM | 9.98 |
| CHEMBL5176563 | — | IC50 | = | 0.1543 | nM | 9.81 |
| CHEMBL1976040 | ADAVOSERTIB | IC50 | = | 0.2837 | nM | 9.55 |