Assay Detail
Binding
CHEMBL5127793
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PARP1 (unknown origin)
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Recent advances in DDR (DNA damage response) inhibitors for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.82 | 9.24 |
| Ki | 1 | 8.48 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3137320 | TALAZOPARIB | 4.0 | 1 | 9.24 |
| CHEMBL521686 | OLAPARIB | 4.0 | 1 | 8.85 |
| CHEMBL1173055 | RUCAPARIB | 4.0 | 1 | 8.77 |
| CHEMBL506871 | VELIPARIB | 3.0 | 1 | 8.48 |
| CHEMBL1094636 | NIRAPARIB | 4.0 | 1 | 8.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3137320 | TALAZOPARIB | IC50 | = | 0.57 | nM | 9.24 |
| CHEMBL521686 | OLAPARIB | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL1173055 | RUCAPARIB | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL506871 | VELIPARIB | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL1094636 | NIRAPARIB | IC50 | = | 3.8 | nM | 8.42 |