Assay Detail
Binding
CHEMBL5127877
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Binding affinity to EZH2-EED (unknown origin) protein interaction assessed as inhibition constant by FP binding assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Recent strategies targeting Embryonic Ectoderm Development (EED) for cancer therapy: Allosteric inhibitors, PPI inhibitors, and PROTACs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 4.56 | 5.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3187985 | APOMORPHINE HYDROCHLORIDE | 4.0 | 1 | 5.54 |
| CHEMBL1228 | OXYPHENBUTAZONE ANHYDROUS | 4.0 | 1 | 4.35 |
| CHEMBL193 | NIFEDIPINE | 4.0 | 1 | 4.18 |
| CHEMBL1213135 | ERGONOVINE MALEATE | 3.0 | 1 | 4.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3187985 | APOMORPHINE HYDROCHLORIDE | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL1228 | OXYPHENBUTAZONE ANHYDROUS | Ki | = | 44500.0 | nM | 4.35 |
| CHEMBL193 | NIFEDIPINE | Ki | = | 66600.0 | nM | 4.18 |
| CHEMBL1213135 | ERGONOVINE MALEATE | Ki | = | 71100.0 | nM | 4.15 |