Assay Detail
Binding
CHEMBL5127922
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of full-length recombinant KDM1A (unknown origin) expressed in Escherichia coli BL21 DE using H3K4Me2 peptide as substrate incubated for 0.5 hrs by Amplex red assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Lysine-specific histone demethylase 1A (CHEMBL6136) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Drug discovery of histone lysine demethylases (KDMs) inhibitors (progress from 2018 to present).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.32 | 6.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3401107 | — | — | 1 | 6.74 |
| CHEMBL3330503 | — | — | 1 | 6.39 |
| CHEMBL19344 | HIGENAMINE | 1.0 | 1 | 5.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3401107 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL3330503 | — | IC50 | = | 407.0 | nM | 6.39 |
| CHEMBL19344 | HIGENAMINE | IC50 | = | 1470.0 | nM | 5.83 |