Assay Detail
Binding
CHEMBL5128050
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to PDE1 derived from bovine brain assessed as inhibition constant using fluorescently-labeled cGMP as substrate incubated for 15 mins by IMAP assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Tissue | Brain |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Therapeutic potential of phosphodiesterase inhibitors for cognitive amelioration in Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 1 | 10.24 | 10.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3770459 | LENRISPODUN PHOSPHATE | 1.0 | 1 | 10.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3770459 | LENRISPODUN PHOSPHATE | Ki | = | 0.058 | nM | 10.24 |