Assay Detail

CHEMBL5128162

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Binding

Inhibition of amyloid beta (unknown origin) production

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Small molecules targeting γ-secretase and their potential biological applications.

Wen J, Liu D, Zhao L.
Eur J Med Chem (2022) 232 : 114169 -114169
PubMed 35176561 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	10.09	10.09

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL392068	—	—	1	10.09

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL392068	—	IC50	=	0.082	nM	10.09