Assay Detail
Functional
CHEMBL5128285
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against SARS-CoV Live SARS-CoV assay and cytotoxicity assessed as reduction in viral cytopathic effect
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome-related coronavirus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV (CHEMBL4303836) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome-related coronavirus |
Publication
Recent applications of vinyl sulfone motif in drug design and discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 10.27 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5190923 | — | — | 1 | 10.40 |
| CHEMBL5185113 | — | — | 1 | 10.40 |
| CHEMBL5181012 | — | — | 1 | 10.40 |
| CHEMBL5198546 | — | — | 1 | 10.40 |
| CHEMBL4743491 | — | — | 1 | 10.40 |
| CHEMBL4755358 | — | — | 1 | 10.40 |
| CHEMBL91704 | K-777 | 2.0 | 1 | 9.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5190923 | — | IC50 | = | 0.04 | nM | 10.40 |
| CHEMBL5185113 | — | IC50 | = | 0.04 | nM | 10.40 |
| CHEMBL5181012 | — | IC50 | = | 0.04 | nM | 10.40 |
| CHEMBL5198546 | — | IC50 | = | 0.04 | nM | 10.40 |
| CHEMBL4743491 | — | IC50 | = | 0.04 | nM | 10.40 |
| CHEMBL4755358 | — | IC50 | = | 0.04 | nM | 10.40 |
| CHEMBL91704 | K-777 | IC50 | = | 0.32 | nM | 9.49 |