Assay Detail
Functional
CHEMBL5128331
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Antiproliferative activity against human SNB-19 cells measured after 72 hrs by WST-1 assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SNB-19 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Tandem construction of biological relevant aliphatic 5-membered N-heterocycles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.20 | 6.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5186709 | — | — | 1 | 6.28 |
| CHEMBL5195718 | — | — | 1 | 5.86 |
| CHEMBL5193650 | — | — | 1 | 5.83 |
| CHEMBL5201334 | — | — | 1 | 5.54 |
| CHEMBL5200730 | — | — | 1 | 5.33 |
| CHEMBL5191949 | — | — | 1 | 4.93 |
| CHEMBL5206595 | — | — | 1 | 4.71 |
| CHEMBL5171283 | — | — | 1 | 4.67 |
| CHEMBL5195587 | — | — | 1 | 4.58 |
| CHEMBL5187581 | — | — | 1 | 4.31 |
| CHEMBL5179466 | — | — | 1 | - |
| CHEMBL5174356 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5186709 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL5195718 | — | IC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL5193650 | — | IC50 | = | 1480.0 | nM | 5.83 |
| CHEMBL5201334 | — | IC50 | = | 2910.0 | nM | 5.54 |
| CHEMBL5200730 | — | IC50 | = | 4640.0 | nM | 5.33 |
| CHEMBL5191949 | — | IC50 | = | 11620.0 | nM | 4.93 |
| CHEMBL5206595 | — | IC50 | = | 19410.0 | nM | 4.71 |
| CHEMBL5171283 | — | IC50 | = | 21540.0 | nM | 4.67 |
| CHEMBL5195587 | — | IC50 | = | 26100.0 | nM | 4.58 |
| CHEMBL5187581 | — | IC50 | = | 48930.0 | nM | 4.31 |
| CHEMBL5179466 | — | IC50 | = | 176620.0 | nM | - |
| CHEMBL5174356 | — | IC50 | = | 166170.0 | nM | - |