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Assay Detail

CHEMBL5128397

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of GSK-3beta (unknown origin)
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Glycogen synthase kinase-3 beta (CHEMBL262)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Development of inhibitors targeting glycogen synthase kinase-3β for human diseases: Strategies to improve selectivity.
Wei J, Wang J, Zhang J, Yang J, Wang G, Wang Y.
Eur J Med Chem (2022) 236 : 114301 -114301
PubMed 35390715 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 6.68 9.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5175996 1 9.40
CHEMBL5186457 1 8.52
CHEMBL5203304 1 8.40
CHEMBL489422 1 8.15
CHEMBL301138 1 7.46
CHEMBL5184987 1 7.14
CHEMBL5074629 1 6.89
CHEMBL489407 1 6.74
CHEMBL5087421 1 6.12
CHEMBL5182770 1 5.70
CHEMBL342402 1 5.52
CHEMBL142764 1 5.00
CHEMBL359135 1 4.30
CHEMBL573428 1 4.16
CHEMBL142415 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5175996 IC50 = 0.4 nM 9.40
CHEMBL5186457 IC50 = 3.0 nM 8.52
CHEMBL5203304 IC50 = 4.0 nM 8.40
CHEMBL489422 IC50 = 7.0 nM 8.15
CHEMBL301138 IC50 = 35.0 nM 7.46
CHEMBL5184987 IC50 = 72.0 nM 7.14
CHEMBL5074629 IC50 = 130.0 nM 6.89
CHEMBL489407 IC50 = 184.0 nM 6.74
CHEMBL5087421 IC50 = 764.0 nM 6.12
CHEMBL5182770 IC50 = 2000.0 nM 5.70
CHEMBL342402 IC50 = 3000.0 nM 5.52
CHEMBL142764 IC50 = 10000.0 nM 5.00
CHEMBL359135 IC50 = 50000.0 nM 4.30
CHEMBL573428 IC50 = 70000.0 nM 4.16
CHEMBL142415 IC50 > 100000.0 nM -