Assay Detail
Binding
CHEMBL5128401
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GSK-3beta (unknown origin) using GS-1 as substrate incubated for 20 mins
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of inhibitors targeting glycogen synthase kinase-3β for human diseases: Strategies to improve selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.16 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL284861 | — | — | 1 | 5.70 |
| CHEMBL26274 | — | — | 1 | 5.52 |
| CHEMBL26218 | — | — | 1 | 5.30 |
| CHEMBL26101 | — | — | 1 | 4.70 |
| CHEMBL25829 | — | — | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL284861 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL26274 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL26218 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL26101 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL25829 | — | IC50 | = | 25000.0 | nM | 4.60 |