Assay Detail
Functional
CHEMBL5128620
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Agonist activity at dopamine D2 receptor (unknown origin)
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of small-molecule compounds and natural products against Parkinson's disease: Pathological mechanism and structural modification.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.31 | 8.70 |
| EC50 | 2 | 7.65 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL155596 | — | — | 1 | 8.70 |
| CHEMBL458088 | — | — | 1 | 8.00 |
| CHEMBL325710 | — | — | 1 | 7.57 |
| CHEMBL5189785 | — | — | 1 | 7.29 |
| CHEMBL132575 | — | — | 1 | 5.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL155596 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL458088 | — | EC50 | = | 9.98 | nM | 8.00 |
| CHEMBL325710 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL5189785 | — | EC50 | = | 51.6 | nM | 7.29 |
| CHEMBL132575 | — | Ki | = | 2234.0 | nM | 5.65 |