Assay Detail
Binding
CHEMBL5128901
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Inhibition of HDAC2 (unknown origin) preincubated for 90 mins
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Comparison of three zinc binding groups for HDAC inhibitors - A potency, selectivity and enzymatic kinetics study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.51 | 6.86 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.86 |
| CHEMBL4451085 | — | — | 1 | 6.79 |
| CHEMBL324053 | — | — | 1 | 5.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | IC50 | = | 137.2 | nM | 6.86 |
| CHEMBL4451085 | — | IC50 | = | 162.8 | nM | 6.79 |
| CHEMBL324053 | — | IC50 | = | 1356.0 | nM | 5.87 |