Assay Detail
Functional
CHEMBL5129276
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Cytotoxicity against multidrug resistance human MES-SA/Dx5 cells assessed as cell growth inhibition incubated for 144 hrs by fluorescence microplate reader assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MES-SA/Dx5 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Cytotoxicity of cinchona alkaloid organocatalysts against MES-SA and MES-SA/Dx5 multidrug-resistant uterine sarcoma cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 4.81 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5170136 | — | — | 1 | 5.82 |
| CHEMBL3746148 | — | — | 1 | 5.55 |
| CHEMBL5178595 | — | — | 1 | 5.41 |
| CHEMBL5177677 | — | — | 1 | 4.96 |
| CHEMBL5204885 | — | — | 1 | 4.92 |
| CHEMBL5186527 | — | — | 1 | 4.85 |
| CHEMBL5174200 | — | — | 1 | 4.68 |
| CHEMBL588934 | HYDROQUININE | -1.0 | 1 | 4.33 |
| CHEMBL5181372 | — | — | 1 | 4.19 |
| CHEMBL170 | QUININE | 4.0 | 1 | 4.17 |
| CHEMBL5174662 | — | — | 1 | 4.07 |
| CHEMBL5181171 | — | — | 1 | - |
| CHEMBL3747587 | — | — | 1 | - |
| CHEMBL5203857 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5170136 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3746148 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL5178595 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL5177677 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL5204885 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL5186527 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL5174200 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL588934 | HYDROQUININE | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL5181372 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL170 | QUININE | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL5174662 | — | IC50 | = | 85000.0 | nM | 4.07 |
| CHEMBL5181171 | — | IC50 | = | 105000.0 | nM | - |
| CHEMBL3747587 | — | IC50 | = | 197000.0 | nM | - |
| CHEMBL5203857 | — | IC50 | = | 161000.0 | nM | - |