Assay Detail
Functional
CHEMBL5129279
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against multidrug resistance human MES-SA/Dx5 cells assessed as cell growth inhibition incubated for 144 hrs in presence of P-gp inhibitor Tariquidar by fluorescence microplate reader assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MES-SA/Dx5 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Cytotoxicity of cinchona alkaloid organocatalysts against MES-SA and MES-SA/Dx5 multidrug-resistant uterine sarcoma cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.05 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5170136 | — | — | 1 | 6.05 |
| CHEMBL5177677 | — | — | 1 | 5.64 |
| CHEMBL5186527 | — | — | 1 | 5.64 |
| CHEMBL5204885 | — | — | 1 | 5.57 |
| CHEMBL5174200 | — | — | 1 | 5.47 |
| CHEMBL170 | QUININE | 4.0 | 1 | 4.37 |
| CHEMBL5181171 | — | — | 1 | 4.32 |
| CHEMBL5181372 | — | — | 1 | 4.30 |
| CHEMBL5174662 | — | — | 1 | 4.10 |
| CHEMBL3747587 | — | — | 1 | - |
| CHEMBL5203857 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5170136 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL5177677 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL5186527 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL5204885 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL5174200 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL170 | QUININE | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL5181171 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL5181372 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL5174662 | — | IC50 | = | 79000.0 | nM | 4.10 |
| CHEMBL3747587 | — | IC50 | = | 121000.0 | nM | - |
| CHEMBL5203857 | — | IC50 | = | 146000.0 | nM | - |