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Assay Detail

CHEMBL5129301

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against Feline immunodeficiency virus infected in IL2 independent FL-4 cells assessed as reduction in viral replication treated for 7 days with daily replacement by qRT-PCR analysis
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Feline immunodeficiency virus
Cell Type FL-4
Confidence 1 — Organism
Curated By Autocuration

Target

Feline immunodeficiency virus (CHEMBL613744)
Type ORGANISM
Organism Feline immunodeficiency virus

Publication

Synthesis and evaluation of 1,2,3-dithiazole inhibitors of the nucleocapsid protein of feline immunodeficiency virus (FIV) as a model for HIV infection.
Laitinen T, Meili T, Koyioni M, Koutentis PA, Poso A, Hofmann-Lehmann R, Asquith CRM.
Bioorg Med Chem (2022) 68 : 116834 -116834
PubMed 35653871 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 33 5.59 7.08

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1724945 1 7.08
CHEMBL5180763 1 6.58
CHEMBL1728676 1 6.54
CHEMBL1698721 1 6.42
CHEMBL5177752 1 6.42
CHEMBL5194848 1 6.38
CHEMBL5202080 1 6.32
CHEMBL4859742 1 6.28
CHEMBL5175202 1 6.26
CHEMBL1712384 1 6.24
CHEMBL1715007 1 6.21
CHEMBL1708334 1 6.19
CHEMBL5197658 1 6.17
CHEMBL1731974 1 6.01
CHEMBL5172680 1 5.70
CHEMBL5185082 1 5.54
CHEMBL1712016 1 5.52
CHEMBL1712193 1 4.92
CHEMBL1734202 1 4.82
CHEMBL4874781 1 4.82
CHEMBL5199984 1 4.70
CHEMBL4868288 1 4.70
CHEMBL4849793 1 4.68
CHEMBL4864771 1 4.66
CHEMBL5189038 1 4.64
CHEMBL4869718 1 4.64
CHEMBL4873897 1 4.58
CHEMBL4874940 1 4.51
CHEMBL4865066 1 4.46
CHEMBL4848106 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1724945 EC50 = 83.0 nM 7.08
CHEMBL5180763 EC50 = 260.0 nM 6.58
CHEMBL1728676 EC50 = 290.0 nM 6.54
CHEMBL1698721 EC50 = 380.0 nM 6.42
CHEMBL5177752 EC50 = 380.0 nM 6.42
CHEMBL5194848 EC50 = 420.0 nM 6.38
CHEMBL5202080 EC50 = 480.0 nM 6.32
CHEMBL4859742 EC50 = 530.0 nM 6.28
CHEMBL5175202 EC50 = 550.0 nM 6.26
CHEMBL1712384 EC50 = 570.0 nM 6.24
CHEMBL1715007 EC50 = 620.0 nM 6.21
CHEMBL1708334 EC50 = 640.0 nM 6.19
CHEMBL5197658 EC50 = 680.0 nM 6.17
CHEMBL1731974 EC50 = 980.0 nM 6.01
CHEMBL5172680 EC50 = 2000.0 nM 5.70
CHEMBL5185082 EC50 = 2900.0 nM 5.54
CHEMBL1712016 EC50 = 3000.0 nM 5.52
CHEMBL1712193 EC50 = 12000.0 nM 4.92
CHEMBL1734202 EC50 = 15000.0 nM 4.82
CHEMBL4874781 EC50 = 15000.0 nM 4.82
CHEMBL5199984 EC50 = 20000.0 nM 4.70
CHEMBL4868288 EC50 = 20000.0 nM 4.70
CHEMBL4849793 EC50 = 21000.0 nM 4.68
CHEMBL4864771 EC50 = 22000.0 nM 4.66
CHEMBL5189038 EC50 = 23000.0 nM 4.64
CHEMBL4869718 EC50 = 23000.0 nM 4.64
CHEMBL4873897 EC50 = 26000.0 nM 4.58
CHEMBL4874940 EC50 = 31000.0 nM 4.51
CHEMBL4865066 EC50 = 35000.0 nM 4.46
CHEMBL4848106 EC50 > 100000.0 nM -
CHEMBL4876624 EC50 > 100000.0 nM -
CHEMBL4856544 EC50 > 100000.0 nM -
CHEMBL5207656 EC50 > 100000.0 nM -