Assay Detail
Binding
CHEMBL5129340
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Inhibition of PU.1 binding to biotin labeled lambdaB DNA (unknown origin) by sensor chip immobilization based surface plasmon resonance analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Not specified |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Drug design and DNA structural research inspired by the Neidle laboratory: DNA minor groove binding and transcription factor inhibition by thiophene diamidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.85 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1232046 | — | — | 1 | 8.05 |
| CHEMBL4853880 | — | — | 1 | 7.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1232046 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4853880 | — | IC50 | = | 23.0 | nM | 7.64 |