Assay Detail
Binding
CHEMBL5129684
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human G9a (913 to 1193 residues) using H3 peptide as substrate measured upto 45 mins in presence of SAM cofactor
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Histone-lysine N-methyltransferase EHMT2 (CHEMBL6032) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of the First-in-Class G9a/GLP Covalent Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.39 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5170450 | — | — | 1 | 7.00 |
| CHEMBL2441082 | — | — | 1 | 6.66 |
| CHEMBL5191615 | — | — | 1 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5170450 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2441082 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL5191615 | — | IC50 | = | 3100.0 | nM | 5.51 |