Assay Detail
Binding
CHEMBL5129685
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human GLP (982 to 1266 residues) using H3 peptide as substrate measured upto 45 mins in presence of SAM cofactor
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Histone-lysine N-methyltransferase EHMT1 (CHEMBL6031) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of the First-in-Class G9a/GLP Covalent Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.45 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5170450 | — | — | 1 | 6.85 |
| CHEMBL2441082 | — | — | 1 | 6.75 |
| CHEMBL5191615 | — | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5170450 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL2441082 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL5191615 | — | IC50 | = | 1800.0 | nM | 5.75 |