Assay Detail
Binding
CHEMBL5129686
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human GLP (982 to 1266 residues) assessed as dissociation constant by isothermal titration calorimetry method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Histone-lysine N-methyltransferase EHMT1 (CHEMBL6031) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of the First-in-Class G9a/GLP Covalent Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 6.88 | 7.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5170450 | — | — | 1 | 7.34 |
| CHEMBL2441082 | — | — | 1 | 7.21 |
| CHEMBL5191615 | — | — | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5170450 | — | Kd | = | 46.0 | nM | 7.34 |
| CHEMBL2441082 | — | Kd | = | 62.0 | nM | 7.21 |
| CHEMBL5191615 | — | Kd | = | 790.0 | nM | 6.10 |