Assay Detail
Binding
CHEMBL5129735
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Binding affinity to human wild type adenosine A3 receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance assay
22
Total Activities
22
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Expi293F |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Surface Plasmon Resonance Screening to Identify Active and Selective Adenosine Receptor Binding Fragments.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 19 | 4.36 | 6.13 |
| Activity | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL477 | ADENOSINE | 4.0 | 1 | 6.13 |
| CHEMBL485745 | GW434756X | — | 1 | 6.13 |
| CHEMBL5208068 | — | — | 1 | 4.75 |
| CHEMBL5204663 | — | — | 1 | 4.72 |
| CHEMBL5184937 | — | — | 1 | 4.44 |
| CHEMBL47633 | — | — | 1 | 4.29 |
| CHEMBL143703 | — | — | 1 | 4.28 |
| CHEMBL4550896 | — | — | 1 | 4.25 |
| CHEMBL5193059 | — | — | 1 | 4.10 |
| CHEMBL1417210 | — | — | 1 | 4.00 |
| CHEMBL5193006 | — | — | 1 | 3.99 |
| CHEMBL337319 | BENZOGUANAMINE | — | 1 | 3.98 |
| CHEMBL3954022 | — | — | 1 | 3.80 |
| CHEMBL5195119 | — | — | 1 | 3.75 |
| CHEMBL1573515 | — | — | 1 | 3.70 |
| CHEMBL5197070 | — | — | 1 | 3.40 |
| CHEMBL336555 | — | — | 1 | - |
| CHEMBL5201800 | — | — | 1 | - |
| CHEMBL5197657 | — | — | 1 | - |
| CHEMBL408564 | — | — | 1 | - |
| CHEMBL160333 | — | — | 1 | - |
| CHEMBL63803 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL477 | ADENOSINE | Kd | = | 740.0 | nM | 6.13 |
| CHEMBL485745 | GW434756X | Kd | = | 740.0 | nM | 6.13 |
| CHEMBL5208068 | — | Kd | = | 18000.0 | nM | 4.75 |
| CHEMBL5204663 | — | Kd | = | 18900.0 | nM | 4.72 |
| CHEMBL5184937 | — | Kd | = | 36500.0 | nM | 4.44 |
| CHEMBL47633 | — | Kd | = | 50700.0 | nM | 4.29 |
| CHEMBL143703 | — | Kd | = | 52000.0 | nM | 4.28 |
| CHEMBL4550896 | — | Kd | = | 56000.0 | nM | 4.25 |
| CHEMBL5193059 | — | Kd | = | 80000.0 | nM | 4.10 |
| CHEMBL1417210 | — | Kd | = | 101000.0 | nM | 4.00 |
| CHEMBL5193006 | — | Kd | = | 102000.0 | nM | 3.99 |
| CHEMBL337319 | BENZOGUANAMINE | Kd | = | 104200.0 | nM | 3.98 |
| CHEMBL3954022 | — | Kd | = | 160000.0 | nM | 3.80 |
| CHEMBL5195119 | — | Kd | = | 180000.0 | nM | 3.75 |
| CHEMBL1573515 | — | Kd | = | 200000.0 | nM | 3.70 |
| CHEMBL5197070 | — | Kd | = | 400000.0 | nM | 3.40 |
| CHEMBL336555 | — | Kd | - | — | - | |
| CHEMBL5201800 | — | Kd | - | — | - | |
| CHEMBL5197657 | — | Kd | - | — | - | |
| CHEMBL408564 | — | Activity | - | — | - | |
| CHEMBL160333 | — | Activity | - | — | - | |
| CHEMBL63803 | — | Activity | - | — | - |