Assay Detail
ADMET
CHEMBL5130156
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human CYP11B2 expressed in Chinese hamster V79 MZh cells using [14C]-deoxycorticosteron as substrate measured after 6 hrs by phosphoimager analysis
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | V79 MZh |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Evaluations of Pyridyl 4,5,6,7-Tetrahydro-4,7-Methanobenzo[<i>d</i>]isoxazoles as Potent and Selective Inhibitors of 11β-Hydroxylase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 5.75 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3099695 | OSILODROSTAT | 4.0 | 1 | 9.30 |
| CHEMBL5198576 | — | — | 1 | 7.24 |
| CHEMBL5177141 | — | — | 1 | 6.95 |
| CHEMBL5209512 | — | — | 1 | 6.48 |
| CHEMBL5201480 | — | — | 1 | 6.40 |
| CHEMBL5175710 | — | — | 1 | 6.38 |
| CHEMBL5186306 | — | — | 1 | 6.32 |
| CHEMBL5196347 | — | — | 1 | 6.10 |
| CHEMBL5171157 | — | — | 1 | 6.04 |
| CHEMBL5184829 | — | — | 1 | 5.95 |
| CHEMBL5195761 | — | — | 1 | 5.84 |
| CHEMBL5174912 | — | — | 1 | 5.78 |
| CHEMBL5203687 | — | — | 1 | 5.68 |
| CHEMBL5175708 | — | — | 1 | 5.66 |
| CHEMBL5204043 | — | — | 1 | 5.64 |
| CHEMBL5204850 | — | — | 1 | 5.62 |
| CHEMBL5199220 | — | — | 1 | 5.58 |
| CHEMBL5175784 | — | — | 1 | 5.55 |
| CHEMBL5183554 | — | — | 1 | 5.53 |
| CHEMBL5171873 | — | — | 1 | 5.52 |
| CHEMBL5186765 | — | — | 1 | 5.42 |
| CHEMBL5197879 | — | — | 1 | 5.40 |
| CHEMBL5185819 | — | — | 1 | 5.40 |
| CHEMBL5189922 | — | — | 1 | 5.37 |
| CHEMBL5173465 | — | — | 1 | 5.37 |
| CHEMBL5189860 | — | — | 1 | 5.35 |
| CHEMBL5175134 | — | — | 1 | 5.29 |
| CHEMBL5202317 | — | — | 1 | 5.25 |
| CHEMBL5171092 | — | — | 1 | 5.24 |
| CHEMBL5204984 | — | — | 1 | 5.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3099695 | OSILODROSTAT | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL5198576 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL5177141 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL5209512 | — | IC50 | = | 329.0 | nM | 6.48 |
| CHEMBL5201480 | — | IC50 | = | 398.0 | nM | 6.40 |
| CHEMBL5175710 | — | IC50 | = | 412.0 | nM | 6.38 |
| CHEMBL5186306 | — | IC50 | = | 477.0 | nM | 6.32 |
| CHEMBL5196347 | — | IC50 | = | 796.0 | nM | 6.10 |
| CHEMBL5171157 | — | IC50 | = | 918.0 | nM | 6.04 |
| CHEMBL5184829 | — | IC50 | = | 1121.0 | nM | 5.95 |
| CHEMBL5195761 | — | IC50 | = | 1428.0 | nM | 5.84 |
| CHEMBL5174912 | — | IC50 | = | 1646.0 | nM | 5.78 |
| CHEMBL5203687 | — | IC50 | = | 2073.0 | nM | 5.68 |
| CHEMBL5175708 | — | IC50 | = | 2181.0 | nM | 5.66 |
| CHEMBL5204043 | — | IC50 | = | 2275.0 | nM | 5.64 |
| CHEMBL5204850 | — | IC50 | = | 2390.0 | nM | 5.62 |
| CHEMBL5199220 | — | IC50 | = | 2602.0 | nM | 5.58 |
| CHEMBL5175784 | — | IC50 | = | 2842.0 | nM | 5.55 |
| CHEMBL5183554 | — | IC50 | = | 2936.0 | nM | 5.53 |
| CHEMBL5171873 | — | IC50 | = | 2993.0 | nM | 5.52 |
| CHEMBL5186765 | — | IC50 | = | 3798.0 | nM | 5.42 |
| CHEMBL5197879 | — | IC50 | = | 4019.0 | nM | 5.40 |
| CHEMBL5185819 | — | IC50 | = | 4007.0 | nM | 5.40 |
| CHEMBL5189922 | — | IC50 | = | 4305.0 | nM | 5.37 |
| CHEMBL5173465 | — | IC50 | = | 4246.0 | nM | 5.37 |
| CHEMBL5189860 | — | IC50 | = | 4451.0 | nM | 5.35 |
| CHEMBL5175134 | — | IC50 | = | 5118.0 | nM | 5.29 |
| CHEMBL5202317 | — | IC50 | = | 5587.0 | nM | 5.25 |
| CHEMBL5171092 | — | IC50 | = | 5751.0 | nM | 5.24 |
| CHEMBL5204984 | — | IC50 | = | 5946.0 | nM | 5.23 |
| CHEMBL5196053 | — | IC50 | = | 5945.0 | nM | 5.23 |
| CHEMBL5192747 | — | IC50 | = | 6221.0 | nM | 5.21 |
| CHEMBL5202486 | — | IC50 | = | 6673.0 | nM | 5.18 |
| CHEMBL5197102 | — | IC50 | = | 6725.0 | nM | 5.17 |
| CHEMBL5203488 | — | IC50 | = | 7714.0 | nM | 5.11 |
| CHEMBL5175297 | — | IC50 | = | 9639.0 | nM | 5.02 |
| CHEMBL5195876 | — | IC50 | = | 9768.0 | nM | 5.01 |