Assay Detail
Functional
CHEMBL5130673
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against mouse MNMCA1 cells assessed as cell survival preincubated for 24 hrs with compound further incubated for 48 hrs in drug free medium by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | MNMCA1 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Balancing Affinity, Selectivity, and Cytotoxicity of Hydrazone-Based G-Quadruplex Ligands for Activation of Interferon β Genes in Cancer Cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.86 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5186764 | — | — | 1 | 5.72 |
| CHEMBL3828801 | — | — | 1 | 5.64 |
| CHEMBL5204469 | — | — | 1 | 4.92 |
| CHEMBL5182391 | — | — | 1 | 4.63 |
| CHEMBL2349416 | PYRIDOSTATIN | — | 1 | 4.57 |
| CHEMBL5180396 | — | — | 1 | 4.54 |
| CHEMBL5207065 | — | — | 1 | 4.45 |
| CHEMBL5177572 | — | — | 1 | 4.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5186764 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL3828801 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL5204469 | — | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL5182391 | — | IC50 | = | 23500.0 | nM | 4.63 |
| CHEMBL2349416 | PYRIDOSTATIN | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL5180396 | — | IC50 | = | 28600.0 | nM | 4.54 |
| CHEMBL5207065 | — | IC50 | = | 35700.0 | nM | 4.45 |
| CHEMBL5177572 | — | IC50 | = | 38500.0 | nM | 4.42 |