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Assay Detail

CHEMBL5131328

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of PARP7 (unknown origin) by HTRF assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Protein mono-ADP-ribosyltransferase TIPARP (CHEMBL2380188)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Recent Discovery of PARP7 Inhibitors as Anticancer Agents.
Kargbo RB.
ACS Med Chem Lett (2022) 13 : 1688 -1690
PubMed 36385937 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 9.00 9.23

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5209116 1 9.23
CHEMBL5177385 1 9.21
CHEMBL5181016 1 9.19
CHEMBL5190796 1 9.10
CHEMBL5183629 1 9.09
CHEMBL5202833 1 9.06
CHEMBL5174619 1 9.02
CHEMBL5173659 1 9.00
CHEMBL5180425 1 8.93
CHEMBL5183278 1 8.91
CHEMBL5193823 1 8.69
CHEMBL5204396 1 8.51

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5209116 IC50 = 0.584 nM 9.23
CHEMBL5177385 IC50 = 0.6114 nM 9.21
CHEMBL5181016 IC50 = 0.648 nM 9.19
CHEMBL5190796 IC50 = 0.802 nM 9.10
CHEMBL5183629 IC50 = 0.806 nM 9.09
CHEMBL5202833 IC50 = 0.87 nM 9.06
CHEMBL5174619 IC50 = 0.966 nM 9.02
CHEMBL5173659 IC50 = 1.006 nM 9.00
CHEMBL5180425 IC50 = 1.173 nM 8.93
CHEMBL5183278 IC50 = 1.243 nM 8.91
CHEMBL5193823 IC50 = 2.031 nM 8.69
CHEMBL5204396 IC50 = 3.106 nM 8.51