Assay Detail
Binding
CHEMBL5131640
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Inhibition of JAK 2 (unknown origin)
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Recent Developments in the Use of Kinase Inhibitors for Management of Viral Infections.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 8.20 | 9.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4303389 | NS-018 | 2.0 | 1 | 9.57 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 9.05 |
| CHEMBL495727 | AT-9283 | 2.0 | 1 | 8.92 |
| CHEMBL4297507 | DELGOCITINIB | 3.0 | 1 | 8.59 |
| CHEMBL1789941 | RUXOLITINIB | 4.0 | 1 | 8.55 |
| CHEMBL1287853 | FEDRATINIB | 4.0 | 1 | 8.52 |
| CHEMBL2107823 | GANDOTINIB | 2.0 | 1 | 8.52 |
| CHEMBL2105759 | BARICITINIB | 4.0 | 1 | 8.24 |
| CHEMBL4116008 | CERDULATINIB | 2.0 | 1 | 8.22 |
| CHEMBL1078178 | MOMELOTINIB | 4.0 | 1 | 7.75 |
| CHEMBL221959 | TOFACITINIB | 4.0 | 1 | 7.70 |
| CHEMBL2035187 | PACRITINIB | 4.0 | 1 | 7.64 |
| CHEMBL3301607 | FILGOTINIB | 4.0 | 1 | 7.55 |
| CHEMBL1944698 | ZOTIRACICLIB | 2.0 | 1 | 7.14 |
| CHEMBL4747591 | — | — | 1 | 7.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4303389 | NS-018 | IC50 | = | 0.27 | nM | 9.57 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL495727 | AT-9283 | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4297507 | DELGOCITINIB | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL1789941 | RUXOLITINIB | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL1287853 | FEDRATINIB | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2107823 | GANDOTINIB | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2105759 | BARICITINIB | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL4116008 | CERDULATINIB | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1078178 | MOMELOTINIB | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL221959 | TOFACITINIB | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2035187 | PACRITINIB | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3301607 | FILGOTINIB | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL1944698 | ZOTIRACICLIB | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL4747591 | — | IC50 | = | 77.0 | nM | 7.11 |