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Assay Detail

CHEMBL5131643

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of JAK 1 (unknown origin)
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Tyrosine-protein kinase JAK1 (CHEMBL2835)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Recent Developments in the Use of Kinase Inhibitors for Management of Viral Infections.
Raghuvanshi R, Bharate SB.
J Med Chem (2022) 65 : 893 -921
PubMed 33539089 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 8.01 8.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3622820 ITACITINIB 3.0 1 8.70
CHEMBL4297507 DELGOCITINIB 3.0 1 8.55
CHEMBL1789941 RUXOLITINIB 4.0 1 8.48
CHEMBL4238926 1 8.41
CHEMBL2105759 BARICITINIB 4.0 1 8.23
CHEMBL3301607 FILGOTINIB 4.0 1 8.00
CHEMBL4650343 IZENCITINIB 2.0 1 8.00
CHEMBL1078178 MOMELOTINIB 4.0 1 7.96
CHEMBL4116008 CERDULATINIB 2.0 1 7.92
CHEMBL4747591 1 7.77
CHEMBL3655081 ABROCITINIB 4.0 1 7.54
CHEMBL3622821 UPADACITINIB 4.0 1 7.37
CHEMBL4577523 GOLIDOCITINIB 2.0 1 7.14

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3622820 ITACITINIB IC50 = 2.0 nM 8.70
CHEMBL4297507 DELGOCITINIB IC50 = 2.8 nM 8.55
CHEMBL1789941 RUXOLITINIB IC50 = 3.3 nM 8.48
CHEMBL4238926 IC50 = 3.9 nM 8.41
CHEMBL2105759 BARICITINIB IC50 = 5.9 nM 8.23
CHEMBL3301607 FILGOTINIB IC50 = 10.0 nM 8.00
CHEMBL4650343 IZENCITINIB IC50 = 10.0 nM 8.00
CHEMBL1078178 MOMELOTINIB IC50 = 11.0 nM 7.96
CHEMBL4116008 CERDULATINIB IC50 = 12.0 nM 7.92
CHEMBL4747591 IC50 = 17.0 nM 7.77
CHEMBL3655081 ABROCITINIB IC50 = 29.0 nM 7.54
CHEMBL3622821 UPADACITINIB IC50 = 43.0 nM 7.37
CHEMBL4577523 GOLIDOCITINIB IC50 = 73.0 nM 7.14