Assay Detail
Binding
CHEMBL5131810
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MEK (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Recent Developments in the Use of Kinase Inhibitors for Management of Viral Infections.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.30 | 9.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 9.48 |
| CHEMBL3182621 | AZD-8330 | 1.0 | 1 | 8.15 |
| CHEMBL1614701 | SELUMETINIB | 4.0 | 1 | 7.85 |
| CHEMBL1236682 | REFAMETINIB | 2.0 | 1 | 7.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 0.33 | nM | 9.48 |
| CHEMBL3182621 | AZD-8330 | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1236682 | REFAMETINIB | IC50 | = | 19.0 | nM | 7.72 |