Assay Detail
Binding
CHEMBL5131978
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SRC (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Proto-oncogene tyrosine-protein kinase Src (CHEMBL267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Kinase Inhibitors as Underexplored Antiviral Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.83 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5416410 | DASATINIB | 4.0 | 1 | 9.30 |
| CHEMBL24828 | VANDETANIB | 4.0 | 1 | 9.10 |
| CHEMBL288441 | BOSUTINIB | 4.0 | 1 | 8.92 |
| CHEMBL217092 | SARACATINIB | 3.0 | 1 | 8.57 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 8.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5416410 | DASATINIB | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL24828 | VANDETANIB | IC50 | = | 0.79 | nM | 9.10 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL217092 | SARACATINIB | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 5.4 | nM | 8.27 |