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Assay Detail

CHEMBL5132040

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of recombinant full length HDAC11 (unknown origin) expressed in insect Sf9 cells by EMSA analysis
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type Sf9
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Histone deacetylase 11 (CHEMBL3310)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Development of HDAC Inhibitors Exhibiting Therapeutic Potential in T-Cell Prolymphocytic Leukemia.
Toutah K, Nawar N, Timonen S, Sorger H, Raouf YS, Bukhari S, von Jan J, Ianevski A, Gawel JM, Olaoye OO, Geletu M, Abdeldayem A, Israelian J, Radu TB, Sedighi A, Bhatti MN, Hassan MM, Manaswiyoungkul P, Shouksmith AE, Neubauer HA, de Araujo ED, Aittokallio T, Krämer OH, Moriggl R, Mustjoki S, Herling M, Gunning PT.
J Med Chem (2021) 64 : 8486 -8509
PubMed 34101461 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 6.60 7.33

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5193507 1 7.33
CHEMBL5198759 1 6.61
CHEMBL5192119 1 6.44
CHEMBL5179295 1 6.03
CHEMBL5082396 1 -
CHEMBL5176422 1 -
CHEMBL5193014 1 -
CHEMBL5201529 1 -
CHEMBL4784006 1 -
CHEMBL5192945 1 -
CHEMBL5181605 1 -
CHEMBL5189543 1 -
CHEMBL5192865 1 -
CHEMBL98 VORINOSTAT 4.0 1 -
CHEMBL2364628 RICOLINOSTAT 2.0 1 -
CHEMBL3693786 CITARINOSTAT 2.0 1 -
CHEMBL5176705 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5193507 IC50 = 47.0 nM 7.33
CHEMBL5198759 IC50 = 246.0 nM 6.61
CHEMBL5192119 IC50 = 364.0 nM 6.44
CHEMBL5179295 IC50 = 941.0 nM 6.03
CHEMBL5082396 IC50 > 1000.0 nM -
CHEMBL5176422 IC50 > 1000.0 nM -
CHEMBL5193014 IC50 > 1000.0 nM -
CHEMBL5201529 IC50 > 1000.0 nM -
CHEMBL4784006 IC50 > 1000.0 nM -
CHEMBL5192945 IC50 > 1000.0 nM -
CHEMBL5181605 IC50 > 1000.0 nM -
CHEMBL5189543 IC50 > 1000.0 nM -
CHEMBL5192865 IC50 > 1000.0 nM -
CHEMBL98 VORINOSTAT IC50 > 1000.0 nM -
CHEMBL2364628 RICOLINOSTAT IC50 > 1000.0 nM -
CHEMBL3693786 CITARINOSTAT IC50 > 1000.0 nM -
CHEMBL5176705 IC50 > 1000.0 nM -