Assay Detail

CHEMBL5132071

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Cytotoxicity against human Mac-1 cells assessed as reduction in cell growth incubated for 72 hrs by Cell titer-blue assay

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	Mac-1
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Development of HDAC Inhibitors Exhibiting Therapeutic Potential in T-Cell Prolymphocytic Leukemia.

Toutah K, Nawar N, Timonen S, Sorger H, Raouf YS, Bukhari S, von Jan J, Ianevski A, Gawel JM, Olaoye OO, Geletu M, Abdeldayem A, Israelian J, Radu TB, Sedighi A, Bhatti MN, Hassan MM, Manaswiyoungkul P, Shouksmith AE, Neubauer HA, de Araujo ED, Aittokallio T, Krämer OH, Moriggl R, Mustjoki S, Herling M, Gunning PT.
J Med Chem (2021) 64 : 8486 -8509
PubMed 34101461 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	6.17	6.34

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL5192865	—	—	1	6.34
CHEMBL3693786	CITARINOSTAT	2.0	1	5.99

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL5192865	—	IC50	=	460.0	nM	6.34
CHEMBL3693786	CITARINOSTAT	IC50	=	1020.0	nM	5.99