Assay Detail
Functional
CHEMBL5132142
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Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Facile and divergent optimization of chromazonarol enabled the identification of simplified drimane meroterpenoids as novel pharmaceutical leads.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 4.95 | 4.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5175485 | — | — | 1 | 4.99 |
| CHEMBL512488 | ALBACONOL | — | 1 | 4.98 |
| CHEMBL5196286 | — | — | 1 | 4.96 |
| CHEMBL5195543 | — | — | 1 | 4.86 |
| CHEMBL459108 | — | — | 1 | - |
| CHEMBL5209172 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5175485 | — | EC50 | = | 10160.0 | nM | 4.99 |
| CHEMBL512488 | ALBACONOL | EC50 | = | 10440.0 | nM | 4.98 |
| CHEMBL5196286 | — | EC50 | = | 11090.0 | nM | 4.96 |
| CHEMBL5195543 | — | EC50 | = | 13920.0 | nM | 4.86 |
| CHEMBL459108 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL5209172 | — | EC50 | > | 50000.0 | nM | - |