Assay Detail
Functional
CHEMBL5132151
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Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-based design, synthesis, and evaluation of inhibitors with high selectivity for PARP-1 over PARP-2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.25 | 4.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1173055 | RUCAPARIB | 4.0 | 1 | 4.49 |
| CHEMBL5203682 | — | — | 1 | 4.32 |
| CHEMBL5208255 | — | — | 1 | 4.12 |
| CHEMBL5182785 | — | — | 1 | 4.07 |
| CHEMBL5197357 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1173055 | RUCAPARIB | IC50 | = | 32210.0 | nM | 4.49 |
| CHEMBL5203682 | — | IC50 | = | 48200.0 | nM | 4.32 |
| CHEMBL5208255 | — | IC50 | = | 75790.0 | nM | 4.12 |
| CHEMBL5182785 | — | IC50 | = | 85910.0 | nM | 4.07 |
| CHEMBL5197357 | — | IC50 | = | 106300.0 | nM | - |