Assay Detail
Functional
CHEMBL5132502
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Antiproliferative activity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by resazurin dye based assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
One-pot three-component synthesis of novel pyrazolo[3,4-b]pyridines as potent antileukemic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.10 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5194796 | — | — | 1 | 5.70 |
| CHEMBL5174977 | — | — | 1 | 5.68 |
| CHEMBL5186373 | — | — | 1 | 5.38 |
| CHEMBL5205749 | — | — | 1 | 5.23 |
| CHEMBL5193078 | — | — | 1 | 5.06 |
| CHEMBL5172171 | — | — | 1 | 5.02 |
| CHEMBL5184279 | — | — | 1 | 4.99 |
| CHEMBL5189295 | — | — | 1 | 4.94 |
| CHEMBL5190114 | — | — | 1 | 4.81 |
| CHEMBL5206130 | — | — | 1 | 4.68 |
| CHEMBL5192198 | — | — | 1 | 4.60 |
| CHEMBL5173748 | — | — | 1 | - |
| CHEMBL5207822 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5194796 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5174977 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL5186373 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL5205749 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL5193078 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL5172171 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL5184279 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL5189295 | — | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL5190114 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL5206130 | — | IC50 | = | 20800.0 | nM | 4.68 |
| CHEMBL5192198 | — | IC50 | = | 24900.0 | nM | 4.60 |
| CHEMBL5173748 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5207822 | — | IC50 | > | 25000.0 | nM | - |