Assay Detail
Functional
CHEMBL5132503
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Antiproliferative activity against human ML-2 cells assessed as reduction in cell viability incubated for 72 hrs by resazurin dye based assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | ML-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
One-pot three-component synthesis of novel pyrazolo[3,4-b]pyridines as potent antileukemic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.48 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5174977 | — | — | 1 | 6.40 |
| CHEMBL5193078 | — | — | 1 | 5.85 |
| CHEMBL5184279 | — | — | 1 | 5.17 |
| CHEMBL5194796 | — | — | 1 | 5.11 |
| CHEMBL5186373 | — | — | 1 | 4.89 |
| CHEMBL5205749 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5174977 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL5193078 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL5184279 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL5194796 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL5186373 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL5205749 | — | IC50 | > | 25000.0 | nM | - |