Assay Detail
Binding
CHEMBL5133250
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Inhibition of BACE1 (unknown origin)
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and discovery of C2-fluoroalkyl iminothiazine dioxides as BACE inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 8.51 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5190011 | — | — | 1 | 9.00 |
| CHEMBL5198665 | — | — | 1 | 9.00 |
| CHEMBL3301601 | VERUBECESTAT | 3.0 | 1 | 8.70 |
| CHEMBL5194897 | — | — | 1 | 8.70 |
| CHEMBL5203401 | — | — | 1 | 8.70 |
| CHEMBL3937515 | — | — | 1 | 8.52 |
| CHEMBL5203915 | — | — | 1 | 8.52 |
| CHEMBL5170892 | — | — | 1 | 8.52 |
| CHEMBL5204704 | — | — | 1 | 8.52 |
| CHEMBL5195553 | — | — | 1 | 8.52 |
| CHEMBL5174392 | — | — | 1 | 8.40 |
| CHEMBL5195634 | — | — | 1 | 8.40 |
| CHEMBL5208596 | — | — | 1 | 8.30 |
| CHEMBL5197842 | — | — | 1 | 8.00 |
| CHEMBL5170080 | — | — | 1 | 7.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5190011 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL5198665 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL3301601 | VERUBECESTAT | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL5194897 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL5203401 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL3937515 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL5203915 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL5170892 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL5204704 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL5195553 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL5174392 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL5195634 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL5208596 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL5197842 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL5170080 | — | Ki | = | 12.0 | nM | 7.92 |