Assay Detail
Toxicity
CHEMBL5133256
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG expressed in HEK cells by voltage clamp assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | HEK |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and discovery of C2-fluoroalkyl iminothiazine dioxides as BACE inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.09 | 5.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3301601 | VERUBECESTAT | 3.0 | 1 | 5.66 |
| CHEMBL5174392 | — | — | 1 | 5.24 |
| CHEMBL3937515 | — | — | 1 | 5.09 |
| CHEMBL5198665 | — | — | 1 | 4.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3301601 | VERUBECESTAT | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL5174392 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL3937515 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL5198665 | — | IC50 | = | 44000.0 | nM | 4.36 |