Assay Detail
Binding
CHEMBL5133290
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Inhibition of PARP1 (unknown origin)
7
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Evaluation of amentoflavone metabolites on PARP-1 inhibition and the potentiation on anti-proliferative effects of carboplatin in A549 cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.65 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL63354 | AMENTOFLAVONE | — | 2 | 6.92 |
| CHEMBL5173467 | — | — | 2 | 6.77 |
| CHEMBL5171234 | — | — | 1 | 6.62 |
| CHEMBL5193533 | — | — | 2 | 6.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL63354 | AMENTOFLAVONE | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL5173467 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL5171234 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL5193533 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL63354 | AMENTOFLAVONE | IC50 | = | 0.1398 | ug.mL-1 | - |
| CHEMBL5173467 | — | IC50 | = | 0.0804 | ug.mL-1 | - |
| CHEMBL5193533 | — | IC50 | = | 0.1158 | ug.mL-1 | - |