Assay Detail
Binding
CHEMBL5133362
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Inhibition of Staphylococcus aureus topoisomerase 4 using pNO1 plasmid DNA as substrate incubated for 30 mins by fluorescence based microtiter plate reader assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Solid-phase synthesis and biological evaluation of piperazine-based novel bacterial topoisomerase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.27 | 5.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5176331 | — | — | 1 | 5.74 |
| CHEMBL5178214 | — | — | 1 | 5.62 |
| CHEMBL5206355 | — | — | 1 | 5.61 |
| CHEMBL5199813 | — | — | 1 | 5.47 |
| CHEMBL5176348 | — | — | 1 | 5.42 |
| CHEMBL5176134 | — | — | 1 | 5.12 |
| CHEMBL2158050 | — | — | 1 | 5.06 |
| CHEMBL8 | CIPROFLOXACIN | 4.0 | 1 | 5.04 |
| CHEMBL5207657 | — | — | 1 | 5.00 |
| CHEMBL5176046 | — | — | 1 | 4.99 |
| CHEMBL5204986 | — | — | 1 | 4.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5176331 | — | IC50 | = | 1810.0 | nM | 5.74 |
| CHEMBL5178214 | — | IC50 | = | 2410.0 | nM | 5.62 |
| CHEMBL5206355 | — | IC50 | = | 2470.0 | nM | 5.61 |
| CHEMBL5199813 | — | IC50 | = | 3360.0 | nM | 5.47 |
| CHEMBL5176348 | — | IC50 | = | 3820.0 | nM | 5.42 |
| CHEMBL5176134 | — | IC50 | = | 7640.0 | nM | 5.12 |
| CHEMBL2158050 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL8 | CIPROFLOXACIN | IC50 | = | 9160.0 | nM | 5.04 |
| CHEMBL5207657 | — | IC50 | = | 9920.0 | nM | 5.00 |
| CHEMBL5176046 | — | IC50 | = | 10160.0 | nM | 4.99 |
| CHEMBL5204986 | — | IC50 | = | 12550.0 | nM | 4.90 |