Assay Detail
Functional
CHEMBL5133377
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Antiproliferative activity against human HeLa cells by CCK8 assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Shikonin N-benzyl matrinic acid ester derivatives as novel telomerase inhibitors with potent activity against lung cancer cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.17 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27323 | — | — | 1 | 7.92 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 6.64 |
| CHEMBL5200525 | — | — | 1 | 5.20 |
| CHEMBL5191447 | — | — | 1 | 5.09 |
| CHEMBL204860 | MATRINE | — | 1 | 5.09 |
| CHEMBL5187734 | — | — | 1 | 5.08 |
| CHEMBL9470 | SHIKONIN | — | 1 | 5.04 |
| CHEMBL5175502 | — | — | 1 | 5.04 |
| CHEMBL5193168 | — | — | 1 | 4.96 |
| CHEMBL5203614 | — | — | 1 | 4.96 |
| CHEMBL5189301 | — | — | 1 | 4.90 |
| CHEMBL5176870 | — | — | 1 | 4.82 |
| CHEMBL5191239 | — | — | 1 | 4.74 |
| CHEMBL5183570 | — | — | 1 | 4.69 |
| CHEMBL5198782 | — | — | 1 | 4.69 |
| CHEMBL5189650 | — | — | 1 | 4.63 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 4.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27323 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL5200525 | — | IC50 | = | 6350.0 | nM | 5.20 |
| CHEMBL5191447 | — | IC50 | = | 8050.0 | nM | 5.09 |
| CHEMBL204860 | MATRINE | IC50 | = | 8120.0 | nM | 5.09 |
| CHEMBL5187734 | — | IC50 | = | 8260.0 | nM | 5.08 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 9230.0 | nM | 5.04 |
| CHEMBL5175502 | — | IC50 | = | 9210.0 | nM | 5.04 |
| CHEMBL5193168 | — | IC50 | = | 11080.0 | nM | 4.96 |
| CHEMBL5203614 | — | IC50 | = | 11020.0 | nM | 4.96 |
| CHEMBL5189301 | — | IC50 | = | 12630.0 | nM | 4.90 |
| CHEMBL5176870 | — | IC50 | = | 15320.0 | nM | 4.82 |
| CHEMBL5191239 | — | IC50 | = | 18010.0 | nM | 4.74 |
| CHEMBL5183570 | — | IC50 | = | 20280.0 | nM | 4.69 |
| CHEMBL5198782 | — | IC50 | = | 20240.0 | nM | 4.69 |
| CHEMBL5189650 | — | IC50 | = | 23180.0 | nM | 4.63 |
| CHEMBL939 | GEFITINIB | IC50 | = | 39320.0 | nM | 4.41 |